Shamattawa RCMP seized nearly 3,000 pills, 100 grams of cannabis and bottles of vodka while searching a home in the community Sept. 26.
A search warrant was obtained for the Wolf Avenue residence as part of an ongoing investigation and police found oxycodone, codeine and alprazolam among more than 2,800 pills.
The street value of the drugs and alcohol is estimated at $105,000.
A 51-year-old man and three women, aged 49, 24 and 21, were arrested as a result of the investigation and remained in police custody as of Sept. 27.
Police continue to investigate.